Five hundred years later, a conference held in Singapore brought together a large group of scholars from widely different national, academic and disciplinary contexts, to analyse and discuss the intricate consequences of Portuguese interactions in Asia over the longue durée. The result of these discussions is a stimulating set of case studies that, as a rule, combine original archival and/or field research with innovative historiographical perspectives. Luso-Asian communities, real and imagined, and Luso-Asian heritage, material and symbolic, are studied with depth and insight. The range of thematic, chronological and geographic areas covered in these proceeding is truly remarkable, showing not only the extraordinary relevance of revisiting Luso-Asian interactions in the longer term, but also the surprising dynamism within an area of studies which seemed on the verge of exhaustion. After all, archives from all over the world, from Rio de Janeiro to London, from Lisbon to Rome, and from Goa to Macao, might still hold some secrets on the subject of Luso-Asian relations, when duly explored by resourceful scholars.