Drifters in search of work, George and his childlike friend Lennie, have nothing in the world except the clothes on their back - and a dream that one day they will have some land of their own. Eventually they find work on a ranch in California's Salinas Valley, but their hopes are dashed as Lennie - struggling against extreme cruelty, and more.

Streetwise George and his big, childlike friend Lennie are drifters, searching for work in the fields and valleys of California. They have nothing except the clothes on their back, and a hope that one day they'll find a place of their own and live the American dream. But dreams come at a price. Gentle giant Lennie doesn't know his own strength, and when they find work at a ranch he gets into trouble with the boss's daughter-in-law. Trouble so bad that even his protector George may not be able to save him...