Stress remains a latent problem that significantly affects the life of the sufferer. Its experience or control may be related to family ties. For this reason, the present study aimed to determine the relationship between manifestations of stress and intrafamily relationships, as well as the association between its components. To this end, 196 secondary school students of both sexes (M=14.40 and SD=1.87) participated and were administered the Fimian, et al. Stress Manifestations Scale (SSI-MS) and the Rivera and Andrade Scale for the Evaluation of Intrafamily Relations (ERI). The results show that there is a significant, negative and average relationship between the variables and their components, with the exception of the intrafamily relationship difficulties dimension, where the relationship is positive. It is concluded that the higher the level of experiencing stress, the lower the reciprocal interconnections between family members.